- Title
- Intralesional PV-10 for the treatment of in-transit melanoma metastases - results of a prospective, non-randomized, single center study
- Creator
- Read, Tavis A.; Smith, Aaron; Thomas, Janine; David, Michael; Foote, Matthew; Wagels, Michael; Barbour, Andrew; Smithers, B. Mark
- Relation
- Journal of Surgical Oncology Vol. 117, Issue 4, p. 579-587
- Publisher Link
- http://dx.doi.org/10.1002/jso.24921
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2018
- Description
- Background: Patients with in-transit melanoma metastases frequently experience high rates of recurrence, limited overall survival and reduced quality of life. After promising results within a Phase II, multi-center study, PV-10 treatment was continued at our institution for patients with in-transit disease. Methodology: An open-label, non-randomized, prospective study was performed at the Princess Alexandra Hospital, Queensland, Australia. Patients were treated with PV-10 in accordance with the treatment protocol established during a previous Phase II study. The primary outcome was the complete response of treated lesions. Results: Forty-five patients were enrolled over a total of 82 treatment episodes from July 2008 to December 2015. With sequential PV-10 treatments the complete response rate was 42% and overall response rate 87% on an intention to treat analysis. The median follow-up duration was 22 months and the median overall survival was 25 months from first PV-10 treatment. Having fewer than 15 metastases at the time of treatment was associated with a complete response (P = 0.03). Conclusions: Intralesional PV-10 provided rapid lesion-specific ablation of melanoma metastases with well-tolerated local effects and minimal systemic adverse events. This therapy should be considered for patients with multiple accessible deposits within the spectrum of low to moderate disease volume.
- Subject
- intralesional; in-transit; melanoma; metastases; PV-10; Rose Bengal
- Identifier
- http://hdl.handle.net/1959.13/1402135
- Identifier
- uon:35010
- Identifier
- ISSN:0022-4790
- Language
- eng
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